Contents
19 February 2020
Vol 12, Issue 531
Vol 12, Issue 531
Research Articles
- A geometrically adaptable heart valve replacement
盛大集团安全吗A biomimetic prosthetic heart valve is geometrically adaptable to accommodate somatic growth and structural asymmetries within the hearts of sheep.
- Anti–PD-1 treatment impairs opioid antinociception in rodents and nonhuman primates
PD-1 regulates opioid signaling in primary sensory and spinal cord neurons and plays a critical role in opioid antinociception.
- Inhibition of the ALDH18A1-MYCN positive feedback loop attenuates MYCN-amplified neuroblastoma growth
The ALDH18A1-MYCN positive feedback loop points to a promising therapeutic target in MYCN盛大集团安全吗-amplified neuroblastoma.
- Filamin A inhibition reduces seizure activity in a mouse model of focal cortical malformations
盛大集团安全吗Inhibiting filamin A has therapeutic effects in a model of tuberous sclerosis complex and a subset of focal cortical dysplasia.
- BRCAness, SLFN11, and RB1 loss predict response to topoisomerase I inhibitors in triple-negative breast cancers
Triple-negative breast cancer xenografts with BRCAness, high expression of SLFN11, and RB1 loss are highly sensitive to topoisomerase I inhibitors.
- Long noncoding RNA SNHG12 integrates a DNA-PK–mediated DNA damage response and vascular senescence
Deficiency of lncRNA SNHG12盛大集团安全吗 impairs DNA damage repair in the vessel wall and predisposes to vascular senescence and atherosclerosis.
Editors' Choice
- How to reverse acetyl-aging
SIRT2 deacetylation of NLRP3 reduces inflammation and reverses age-related glucose dysregulation.
- Microbiome goes to the ICU
Lung microbiota predicts outcomes in critically ill mechanically ventilated patients.
- Microfluidic modeling of bone marrow pathophysiology
Human bone-marrow-on-a-chip improves drug studies of hematopoietic cell function and identifies a neutrophil maturation defect in a genetic disorder.
About The Cover
ONLINE COVER Adaptable with Age. This illustration shows cross sections of hearts with replacement pulmonary valves (white). As the size of the heart increases during developmental growth (left to right, following the white curve in background), the valve is expanded. Children with congenital heart valve disease often undergo multiple surgeries because replacement valves do not accommodate heart growth. To reduce open-heart surgical burden, Hofferberth et al.盛大集团安全吗 developed a geometrically adaptable bileaflet prosthetic valve that mimics human venous valves. The polymer-based valves could be mechanically expanded using a balloon catheter, facilitating unidirectional fluid flow without leakage in vitro and blood flow when implanted in growing lambs for 10 weeks. This nonliving valve design could support somatic growth. [CREDIT: SOPHIE C. HOFFERBERTH, LARA TOMHOLT, JAMES C. WEAVER]